joeb631a
Well-Known Member
we all would have done the same..
And it was steak ,better than the maple kind bacon.
The Original Old Farts Club
- Thread starter yooper420
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And it was steak ,better than the maple kind bacon.
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Thats why I was lurkin I was drinkin my coffee.
Nice view thanks for that!
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and that is a good thing
coffee , cannabis , and caffeine for the win
i like to relax first thing when I get up ,after a hard nights sleep , I need some peace and quiet!
like the sound of the gentle surf crashing on the peaceful shorelines of Uluwatu…
Uluwatu Uluwatu Uluwatu
such a fun word , sort of like salsa
So much to learn....YOU DON'T TELL THEM!LOL No...I wouldn't do that.
Besides...my bride has ZERO sense of humor. She's, uh...stoic. Solemn. Even stern. I tell her that she's payback for my prior wilding days. Because I did some of that...and she never did.
Bubba
Me too. Colder every year it seems. I should have been a surfer, constantly chasing summers across the globe!
Bubba
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when the weed kicks in
NewbOldster
Well-Known Member
I GOT A BIG MOUTH, OKAY? lol
NewbOldster
Well-Known Member
Eyeball absorption, eh? I usually just smoke the stuff.
Smh....
NewbOldster
Well-Known Member
I can't keep secrets. A-PAIR-ently I talk in my sleep.
Tea bags are supposed to reduce the bags under your eyes! Shes chillaxin after a long nite of partyin
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So you ate the dog spit one then. Lol.LOL No...I wouldn't do that.
Besides...my bride has ZERO sense of humor. She's, uh...stoic. Solemn. Even stern. I tell her that she's payback for my prior wilding days. Because I did some of that...and she never did.
Bubba
Oh that's bad. If she learns that you're cooked!I can't keep secrets. A-PAIR-ently I talk in my sleep.
NewbOldster
Well-Known Member
I know...I was jus' bein' facetious.
NewbOldster
Well-Known Member
She already knows it. How do you think I found out? lol
Unca Walt
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Awright, Pilgrims... How's this quote pulled from the middle of an article as a teaser:
"With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces," says Prof. Zimmer. "When the activity of the cannabinoid system declines, we find rapid ageing in the brain."
So I thank each of youse pioneers for keeping me from drooling too much.
Here's the whole Science Daily article. I accidentally found it filed in my own articles section of my 'puter for some strange reason.
Memory performance decreases with increasing age. Cannabis can reverse these ageing processes in the brain. This was shown in mice by scientists at the University of Bonn with their colleagues at The Hebrew University of Jerusalem (Israel). Old animals were able to regress to the state of two-month-old mice with a prolonged low-dose treatment with a cannabis active ingredient. This opens up new options, for instance, when it comes to treating dementia. The results are now presented in the journal Nature Medicine.
Like any other organ, our brain ages. As a result, cognitive ability also decreases with increasing age. This can be noticed, for instance, in that it becomes more difficult to learn new things or devote attention to several things at the same time. This process is normal, but can also promote dementia. Researchers have long been looking for ways to slow down or even reverse this process.
Scientists at the University of Bonn and The Hebrew University of Jerusalem (Israel) have now achieved this in mice. These animals have a relatively short life expectancy in nature and display pronounced cognitive deficits even at twelve months of age. The researchers administered a small quantity of THC, the active ingredient in the hemp plant (cannabis), to mice aged two, twelve and 18 months over a period of four weeks.
Afterwards, they tested learning capacity and memory performance in the animals -- including, for instance, orientation skills and the recognition of other mice. Mice who were only given a placebo displayed natural age-dependent learning and memory losses. In contrast, the cognitive functions of the animals treated with cannabis were just as good as the two-month-old control animals. "The treatment completely reversed the loss of performance in the old animals," reported Prof. Andreas Zimmer from the Institute of Molecular Psychiatry at the University of Bonn and member of the Cluster of Excellence ImmunoSensation.
Years of meticulous research
This treatment success is the result of years of meticulous research. First of all, the scientists discovered that the brain ages much faster when mice do not possess any functional receptors for THC. These cannabinoid 1 (CB1) receptors are proteins to which the substances dock and thus trigger a signal chain. CB1 is also the reason for the intoxicating effect of THC in cannabis products, such as hashish or marihuana, which accumulate at the receptor. THC imitates the effect of cannabinoids produced naturally in the body, which fulfil important functions in the brain. "With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces," says Prof. Zimmer. "When the activity of the cannabinoid system declines, we find rapid ageing in the brain."
To discover precisely what effect the THC treatment has in old mice, the researchers examined the brain tissue and gene activity of the treated mice. The findings were surprising: the molecular signature no longer corresponded to that of old animals, but was instead very similar to that of young animals. The number of links between the nerve cells in the brain also increased again, which is an important prerequisite for learning ability. "It looked as though the THC treatment turned back the molecular clock," says Zimmer.
Next step: clinical trial on humans
A low dose of the administered THC was chosen so that there was no intoxicating effect in the mice. Cannabis products are already permitted as medications, for instance as pain relief. As a next step, the researchers want to conduct a clinical trial to investigate whether THC also reverses ageing processes in the brain in humans and can increase cognitive ability.
The North Rhine-Westphalia science minister Svenja Schulze appeared thrilled by the study: "The promotion of knowledge-led research is indispensable, as it is the breeding ground for all matters relating to application. Although there is a long path from mice to humans, I feel extremely positive about the prospect that THC could be used to treat dementia, for instance."
"With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces," says Prof. Zimmer. "When the activity of the cannabinoid system declines, we find rapid ageing in the brain."
So I thank each of youse pioneers for keeping me from drooling too much.
Here's the whole Science Daily article. I accidentally found it filed in my own articles section of my 'puter for some strange reason.
Cannabis Reverses Aging Processes In The Brain
Cannabis reverses aging processes in the brain, study suggests
Cannabis reverses aging processes in the brain, study suggests
Memory performance decreases with increasing age. Cannabis can reverse these ageing processes in the brain. This was shown in mice by scientists at the University of Bonn with their colleagues at The Hebrew University of Jerusalem (Israel). Old animals were able to regress to the state of two-month-old mice with a prolonged low-dose treatment with a cannabis active ingredient. This opens up new options, for instance, when it comes to treating dementia. The results are now presented in the journal Nature Medicine.
Like any other organ, our brain ages. As a result, cognitive ability also decreases with increasing age. This can be noticed, for instance, in that it becomes more difficult to learn new things or devote attention to several things at the same time. This process is normal, but can also promote dementia. Researchers have long been looking for ways to slow down or even reverse this process.
Scientists at the University of Bonn and The Hebrew University of Jerusalem (Israel) have now achieved this in mice. These animals have a relatively short life expectancy in nature and display pronounced cognitive deficits even at twelve months of age. The researchers administered a small quantity of THC, the active ingredient in the hemp plant (cannabis), to mice aged two, twelve and 18 months over a period of four weeks.
Afterwards, they tested learning capacity and memory performance in the animals -- including, for instance, orientation skills and the recognition of other mice. Mice who were only given a placebo displayed natural age-dependent learning and memory losses. In contrast, the cognitive functions of the animals treated with cannabis were just as good as the two-month-old control animals. "The treatment completely reversed the loss of performance in the old animals," reported Prof. Andreas Zimmer from the Institute of Molecular Psychiatry at the University of Bonn and member of the Cluster of Excellence ImmunoSensation.
Years of meticulous research
This treatment success is the result of years of meticulous research. First of all, the scientists discovered that the brain ages much faster when mice do not possess any functional receptors for THC. These cannabinoid 1 (CB1) receptors are proteins to which the substances dock and thus trigger a signal chain. CB1 is also the reason for the intoxicating effect of THC in cannabis products, such as hashish or marihuana, which accumulate at the receptor. THC imitates the effect of cannabinoids produced naturally in the body, which fulfil important functions in the brain. "With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces," says Prof. Zimmer. "When the activity of the cannabinoid system declines, we find rapid ageing in the brain."
To discover precisely what effect the THC treatment has in old mice, the researchers examined the brain tissue and gene activity of the treated mice. The findings were surprising: the molecular signature no longer corresponded to that of old animals, but was instead very similar to that of young animals. The number of links between the nerve cells in the brain also increased again, which is an important prerequisite for learning ability. "It looked as though the THC treatment turned back the molecular clock," says Zimmer.
Next step: clinical trial on humans
A low dose of the administered THC was chosen so that there was no intoxicating effect in the mice. Cannabis products are already permitted as medications, for instance as pain relief. As a next step, the researchers want to conduct a clinical trial to investigate whether THC also reverses ageing processes in the brain in humans and can increase cognitive ability.
The North Rhine-Westphalia science minister Svenja Schulze appeared thrilled by the study: "The promotion of knowledge-led research is indispensable, as it is the breeding ground for all matters relating to application. Although there is a long path from mice to humans, I feel extremely positive about the prospect that THC could be used to treat dementia, for instance."
So that's why I'm so smart.
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Unca , we have both read it and seen it with our own eyes
we have seen people slipping into Alzheimer’s and when they were given full spectrum cannabis oil , they would come out of that place , like they would wake up , they will start dreaming , talking about the past , and remembering things
generally engaging in life
take them off the oil , and they start to slip back into the empty chambers of forgetfulness
our brains NEED cannabinoids!
