I change my flower res every 2 weeks. I measure my ppms regularly, and they have never dropped more then 100. I do notice that the res starts to smell every once in a while after 9 or 10 days, so I just put a bit of h2o2 into the res, and this takes care of everything.
My mother res gets changed every couple of months. I actually change it when my moms start turning a bit yellow.
Nutes aren't too expensive, but I see no need wasting money when it is not needed.