I don't have any scientific proof, but life experience has taught me well. Had an acquaintance that was called out of town for two weeks on an emergency and had to leave his plants unattended. When he harvested, they were about 75% amber trics. He gave me a bag and told me to wait 'til I got home and in for the night before I tried it.
Wish I'd have pulled a chair close to the door. If the house had of caught fire, I'd had to try and crawl my way outside. Took me legs right out from under me. It was a race between when the effects would ease up enough for me to walk or my bladder would burst from holding in a raging piss.