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The csnnabutter I made out of my 2+ year old seeded trim and popcorn is pretty potent. Almost devastating. My understanding is that the majority of cannabinoids are found in the trichomes. The seeded buds were covered with trichomes. Trichomes are in theory made to provide protection to the plant from UV rays(like sunscreen). Evolution would favor genetics that protect their offspring(seeds) from harmful UV light. I tried to find scientific papers addressing seeded vs unseeded cannabinoid concentration but couldn’t find any. A grower certainly gets more weight of material that can be smoked in sinsemillia but I can’t find evidence that there is any difference in what we perceive as potentcy.